Continuous nicotine exposure does not affect resurgence of alcohol seeking in rats
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چکیده
منابع مشابه
The dual orexin receptor antagonist TCS1102 does not affect reinstatement of nicotine-seeking
The orexin/hypocretin system is important for appetitive motivation towards multiple drugs of abuse, including nicotine. Both OX1 and OX2 receptors individually have been shown to influence nicotine self-administration and reinstatement. Due to the increasing clinical use of dual orexin receptor antagonists in the treatment of disorders such as insomnia, we examined whether a dual orexin recept...
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Concomitant access to drugs of abuse and alternative rewards such as sucrose has been shown to decrease addiction-related behaviors in animals. Here we investigated whether access to sucrose during abstinence in contexts that are temporally and physically distinct from drug-related contexts could reduce subsequent drug seeking. In addition, we investigated whether a history of cocaine self-admi...
متن کاملNicotine modulates alcohol-seeking and relapse by alcohol-preferring (P) rats in a time-dependent manner.
BACKGROUND Alcohol is frequently co-abused with smoking. In humans, nicotine use can increase alcohol craving and consumption. The objectives of the current study were to assess the acute effects of nicotine on alcohol seeking and relapse at 2 different time points. METHODS Adult female alcohol-preferring (P) rats were trained in 2-lever operant chambers to self-administer 15% ethanol (EtOH) ...
متن کاملPrenatal alcohol exposure did not affect impulsivity in rats that performed delay or probability discounting tasks
Individuals who fall under the spectrum of the Fetal Alcohol Syndrome have a higher prevalence of several cognitive disturbances, including a greater probability of being diagnosed with attention-deficit hyperactivity disorder (ADHD). Some of these effects, such as hyperactivity and attentional impairments, are already well established in the literature. The assessment of impulsive choice, howe...
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Background: This study was planned to examine the effects of whole-body exposure to GSM-950 MHz electromagnetic fields (EMFs) on acquisition and consolidation of spatial memory in rats using a water maze task. Materials and Methods: In experiment 1, the animals were given two blocks of five trials per day for three consecutive days in a water maze task. The interval between blocks was 4h...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2018
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0202230